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This book brings awareness to a neglected condition that is nevertheless prevalent world-wide. Much focus is justly given to pulmonary tuberculosis, one of the key medical scourges of humanity, but this disease also often manifests itself in organs outside of the lungs. There is however a surprising lack of information available on extrapulmonary TB, which this book aims to remedy. Specifically, research, as well as epidemiology, diagnosis, and treatment options, are discussed in detail by an international list of experts. This comprehensive product serves as a valuable resource to numerous fields of medicine due to the presence of extrapulmonary tuberculosis throughout the human body. .

Tuberculosis. --- Immunology. --- Emerging infectious diseases. --- Infectious Diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Immunobiology --- Life sciences --- Serology --- Infectious diseases.

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This book reviews the role of each cell subset in the skin, providing the basics for understanding skin immunology and the mechanisms of skin diseases. The skin is one of the immune organs and is continually exposed to foreign antigens and external stimuli that must be monitored and characterized for possible elimination. Upon exposure to foreign antigens, the skin can elicit a variety of immune responses in harmony with skin components that include keratinocytes, dendritic cell subsets, mast cells, basophils, fibroblasts, macrophages, gamma-delta T cells, neutrophils, myeloid-derived suppressor cells, vascular and lymphatic cells, hair follicles, platelets, and adipose tissues, among others. In the past 10 years, knowledge of immunology has expanded drastically in areas such as innate immunity (Toll-like receptors, C-type lectins), and host defenses to bacteria and viruses, and this increased knowledge has led to the development of more effective treatment of psoriasis and other skin diseases. This book provides updates on the mechanisms of skin diseases including contact dermatitis, atopic dermatitis, psoriasis, urticaria, drug eruption, bullous diseases, anaphylaxis, graft-versus-host disease, rosacea, lymphoma, photodermatology, and collagen vascular diseases. Understanding the basics of skin immunology will help clinicians and dermatologists use new therapeutics such as biologics efficiently. Serving as an intermediary between basic science and clinical medicine, this book gives readers the opportunity to understand and marvel at the mystery and fascination of skin immunology.

Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Immunology. --- Dermatology. --- Emerging infectious diseases. --- Infectious Diseases. --- Medicine --- Skin --- Immunobiology --- Life sciences --- Serology --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Diseases --- Infectious diseases.

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Endophthalmitis is a serious eye infection that can cause blindness if not promptly diagnosed and appropriately treated.  The goals of this book are to provide the latest information about endophthalmitis and offer recommendations for diagnosis and treatment.  Each chapter is written by experts in the field with the practicing clinician in mind.  Several chapters focus on the major types of endophthalmitis such as postoperative, post-intravitreal injection, bleb-related, exogenous fungal, chronic, and endogenous endophthalmitis.  Other chapters describe endophthalmitis in special populations such as diabetic or immunocompromised hosts or those with a glaucoma drainage device, keratoprosthesis, or other artificial implant.  Also included are chapters that provide an overview of endophthalmitis as seen around the world, summarize current understanding of endophthalmitis pathogenesis, describe the latest microbiologic and molecular diagnostic techniques, and discuss emerging problems such as multidrug-resistant pathogens.  A final chapter offers recommendations for ways to prevent this devastating eye infection.

Ophthalmology & Optometry --- Medicine --- Health & Biological Sciences --- Eye --- Cataract --- Infections. --- Surgery --- Complications. --- Complications and sequelae --- Ophthalmology. --- Emerging infectious diseases. --- Infectious Diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Diseases --- Infectious diseases.

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This text provides essential modeling skills and methodology for the study of infectious diseases through a one-semester modeling course or directed individual studies. The book includes mathematical descriptions of epidemiological concepts, and uses classic epidemic models to introduce different mathematical methods in model analysis. Matlab codes are also included for numerical implementations. It is primarily written for upper undergraduate and beginning graduate students in mathematical sciences who have an interest in mathematical modeling of infectious diseases. Although written in a rigorous mathematical manner, the style is not unfriendly to non-mathematicians.

Mathematics. --- Infectious diseases. --- Epidemiology. --- Mathematics of Planet Earth. --- Infectious Diseases. --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Diseases --- Public health --- Math --- Science --- Mathematical models.

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Escherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targets and development of vaccines that offer lasting protection. This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development.

Escherichia coli. --- E. coli (Bacterium) --- Escherichia --- Microbiology. --- Emerging infectious diseases. --- Bacteriology. --- Medical Microbiology. --- Infectious Diseases. --- Microbiology --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Microbial biology --- Biology --- Microorganisms --- Medical microbiology. --- Infectious diseases.